Case 2

2Sections demonstrate a well-circumscribed mass involving the parenchyma of the right lobe of thyroid.

Capsule is thin and intact (no signs of invasion).

The tumor cells are arranged in follicular pattern and possess clear nuclei, some of which contain nuclear grooves and intranuclear pseudoinclusions.

Distribution of vesicular nuclei is uneven, with focal grouping.

There is a small area (less <1% of the whole lesion) with papillary pattern.

All resection margins are free of tumor cells. No extrathyroidal invasion is evident.

Extra: In the left lobe of thyroid, there is an adenomatous goiter composed of follicles of varying sizes containing colliodal material, myxoid stroma and a few foci of recent and old hemorrhage. The follicles are lined by benign flat cuboidal follicular cells. Scattered lymphoid tissue and germinal centers are also present. The remaining thyroid gland is unremarkable.

NIFTP (Non-Invasive Follicular Thyroid neoplasm with Papillary-like nuclear features),

a tumor formerly known as “non-invasive encapsulated follicular variant of papillary thyroid carcinoma (EFVPT)”

All details and diagnostic criteria:

Andrey Bychkov


Department of Pathology Faculty of Medicine

Chulalongkorn University